AI Can Be Used to Predict Treatment Adherence

Medication adherence interventions to prompt medication refills are often executed by centralized call centers and retail pharmacies. Researchers used artificial intelligence (AI) to evaluate which patients will achieve the greatest increase in prescription refill rates by receiving both call center and pharmacy-provided interventions. The researchers found that AI can effectively select which patients will achieve greater increases in refill rates by adding a pharmacy-based intervention to a call center intervention. The results of the study were presented during AMCP eLearning Days in a poster presentation titled “Efficacy of Using Artificial Intelligence to Determine Whether Adding Pharmacy-Based Interventions in Addition to Call Center Interventions Will Improve Patients’ Refill Rates.”

The randomized, controlled trial used data from a pharmacy chain and a call center that provides medication adherence interventions.

The study included high-risk patients who had a prescription fill due soon or were late on filling a prescription for RAS antagonists, non-insulin anti-diabetics, and/or statin medications. Patients were selected for adherence interventions based on AI, and there were two intervention options. One was a reminder call from a centralized call center; the other was both a call from the call center and an intervention from the patient’s retail pharmacy. Patients were further predicted as to whether adding the retail pharmacy outreach to the centralized call center outreach would have a high (Group A; n=4,011) or low (Group B; n=8,026) impact on their likelihood of filling a prescription within 14 days.

Patients in Group A who received both interventions were 51.9% more likely to refill a prescription within 14 days than patients in Group A who were randomized to only receive the call center intervention (P<0.001). Patients in Group B who received both interventions were 24.5% more likely to refill a prescription within 14 days than patients in Group B who were randomized to only receive the call center intervention (P<0.001).

The study was sponsored by AllazoHealth.

Flores C, Jones C. Efficacy of Using Artificial Intelligence to Determine Whether Adding Pharmacy-Based Interventions in Addition to Call Center Interventions Will Improve Patients’ Refill Rates. Abstract U33. Presented during AMCP eLearning Days, April 20-24.